Abstract
Objectives The association between increased resistance to flow in the uterine artery and adverse pregnancy outcomes has been demonstrated, but there are no studies evaluating their relationship with outcomes after birth. Our aim was to evaluate the relationship of the pulsatility index of the uterine artery in the second trimester of pregnancy with the neurodevelopment of children in the second year of life. Methods A cohort study was performed involving 1370 women with singleton pregnancies. Pulsatility index of the uterine artery between 20 and 25 weeks was obtained. The psychomotor development of the children of these women was evaluated in the second year of life with the Bayley Scales of Infant and Toddler Development Third Edition (Bayley-III Screening). Results The mean age of pregnant women was 25.8 years and the mean gestational age of 23.6 weeks review. The average pulsatility index of the uterine artery was 0.89 and 1.47 for the 95th percentile. Evaluation of children, showed no increased risk associated with delay in pulsatility index of uterine artery greater than or equal to the 95th percentile development (cognitive performance: RR 0.76, 95% CI 0.3–1.96, receptive communication: RR 1.17, 95% CI 0.46–3.01, expressive communication: RR 0.66, 95% CI 0 0.67–1, 36, fine motor: RR 1.26, 95% CI 0.5–3.27, gross motor: RR 1.14 95% CI 0.44–2.94). Conclusions The high flow resistance of the uterine artery in the second quarter, without deleting other perinatal factors, cannot be considered as a risk factor for the delay in child development. Additional studies should be performed excluding the perinatal risk factors such as prematurity that may adversely affect psychomotor performance of children. Disclosures M.M. Okido: None. L.B. Martins: None. T.V. Bertagnolli: None. M.A. Barbieri: None. H. Bettiol: None. V.C. Cardoso: None. R.C. Cavalli: None.
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