248: Pulmonary allograft tolerance can be incuced across a class I MHC barrier in swine sensitized to MHC class I allopeptides prior to transplantation

Abstract

We have previously induced tolerance to class I disparate lung allografts in miniature swine using an intensive 12-day course of tacrolimus. Here, we test whether a similar tolerant state can be induced in swine sensitized with immunogenic MHC class I allopeptides prior to transplantation.