247 Comparison of liposome encapsulated retinol and pure retinol on anti-aging gene expression using human skin model

Abstract

Retinol is the pure form of pro-vitamin A and is produced by the breakdown of its precursor β-carotene, a red-orange pigment in the body. Retinol is metabolized to its active form retinoic acid which binds to retinoic acid receptors to transactivate barrier function, anti-inflammation, and extracellular matrix gene expression. Topical retinol application has been demonstrated in clinical studies to improve hyperpigmentation and wrinkles in chronologically aged and photodamaged skin. Pure retinol is highly sensitive to visible and UV light, readily undergoes oxidation and discoloration.