Abstract
Background: The one-step nucleic acid amplification (OSNA) assay quantifies the cytokeratin 19 (CK19) messenger RNA copy number, which is currently being used for assessment of axillary sentinel lymph node (SLN) status in breast cancer. The total tumour load (TTL), defined as the total amount of CK19 mRNA copies in all positive SLNs, may help predicting additional metastatic axillary involvement besides SLN. There is evidence suggesting that palpable and non-palpable breast tumours manifest distinct pathological features, making tumour palpability a putative predictive factor of axillary lymph node involvement.
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