246 Inhibition of Cutibacterium acnes virulence to reduce oily skin imperfections

Abstract

Whereas the transitory, i.e virulent Cutibacterium acnes (CA) predominates over the resident commensal form in acne prone skin, in oily skin, the expression of both bacteria types is not disturbed and using antibacterial agents is not the right solution. Therefore, it’s more appropriate to limit bacterial virulence through measures such as targeting the lipase activity that catalyzes the release of irritant FFAs from sebum triglycerides, such as oleic acid, which trigger IL1a release, thereby disrupting keratinocyte differentiation and promoting comedo formation.