Abstract
Our purpose is to investigate Propolis and Nigella sativa oil (NSO) for their antioxidant effects on the liver tissue of rats exposed to ionizing radiation. A total of 32 Sprague–Dawley rats were divided into five groups to test the radioprotective effectiveness of of Propolis and NSO administered by orogastric tube. Appropriate control group was also studied. Biochemical parameters in liver tissue of rats were determined by spectrophotometer. Xanthine oxidase (XO), nitric oxide synthase (NOS), superoxide dismutase (SOD) activities, nitric oxide (NO●) and malondialdehyde (MDA) levels were higher in IR group while glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px) level in the IR group were lower in this group when compared to the other groups. GST activity in IR plus Propolis group was statistically higher than in all other groups. Conclusion Propolis and NSO clearly protect liver tissue from radiation-induced oxidative/nitrosative stress.
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