Abstract
Several case reports exist linking propoxyphene, a drug structurally related to methadone, to hypoglycemia. Morphine-induced hypoglycemia in mice has been shown to be inhibited by co-administration of naloxone. Blunted responses to insulin-induced hypoglycemia as well as delayed and inhibited insulin responses to food ingestion have been demonstrated in methadone maintenance patients. However, there are no published reports of methadone causing or contributing to symptomatic hypoglycemia. In this case, a 46 year old non-diabetic man with stage IV rectosigmoid cancer and renal failure that improved after nephrostomy tubes placement presented with severe abdominal pain due to a rapidly growing right pelvic wall mass.
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