Diabetes mellitus (DM) is the 7th leading cause of death in the U.S. in 2015. According to Center of Disease Control (CDC), prevalence of DM has increased in recent years affecting 9.4% of U.S. population and 12.5% of New York City (NYC) population in 2015. Increased DM prevalence is a worldwide trend associated with increasing age of the population. Aim: To determine prevalence and severity of diabetes/prediabetics in NYC Chinese population in comparison with those of non-Chinese patients. Methods: We obtained and analyze HMO A1C data of 276,854 Chinese (age 18-98 with median of 51 years, 55% female, 45% male, representing the largest population studies) and non-Chinese sampling population in NYC from January 2015 to October 2018 using BioReference Lab. Patients (57,612 Chinese, 49,548 non-Chinese) classified as prediabetics with A1C between 5.7-6.4% upon initial A1C test had follow-up test after management according to CDC Prediabetic management protocol. Results: Of 197,487 Chinese who had A1C test indicated prevalence of 18.5% diabetes, 45.6% of prediabetic and 35.6% nondiabetics. The male group had a higher incidence of diabetes than females (21% vs. 16.5%). Among 1,341,054 non-Chinese clients, there were 51.6% nondiabetics, 31.4% prediabetics and 18.0% diabetes. The severity of diabetes with respect to A1C data in 36,596 Chinese were 6.5-7.4, 57%; 7.5-9.0, 27%; >9.0, 16% whereas in 241,180 non-Chinese they were 44%, 29% and 28%, respectively. Among Chinese prediabetics, 30% reversed to nondiabetics and 5.7% progressed to diabetic categories, whereas among non-Chinese prediabetics, 25.8% reverse to nondiabetics and 11.1% progressed to diabetics during the study time. Conclusion: Prevalence of diabetes in NYC population is higher than that found in 2015. More severe diabetes with higher A1C levels was found in non-Chinese than Chinese patients. The NYC Chinese had higher incidence of prediabetics but had better management outcome than non-Chinese community. Disclosure G. Liu: None. J.D. George: None. J.W. Sharp: None. A. Hu: None. T. Chang: None.

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