2430-PUB: Analysis of Transient Elastography Data and the Risk of Metabolic Syndrome

Abstract

Aim: To investigate the correlation between Fibroscan® data controlled attenuation parameter (CAP), liver stiffness measurement (LSM) and metabolic syndrome (MetS) components. Methods: A total of 817 subjects in this year’s staffs physical checkup screening for nonalcoholic fatty liver disease (NAFLD) were recruited. Questionnaires were filled, anthropometries including neck and waist circumferences, body mass index were collected. Fasting glucose, lipid profiles, serum insulin and plasma adiponectin were measured. Controlled attenuation parameter and LSM were recorded using FibroScan®. The subjects were divided into MetS and control groups. Clinical characteristics were compared. Independent predictors for MetS were analyzed. Results: The CAP (277 ± 48 vs. 237 ± 44 dB/m, P<0.001), LSM (4.9 ± 2.2 vs. 4. 1 ± 1.0kpa, P<0.001), neck circumference (37.1 ± 3.3 vs. 34.1 ± 3.0, P<0.001) and fasting insulin (9.3 ± 4.7 vs. 5. 7 ± 2.9μU/mL, P<0.001) were significantly elevated in the MetS group, whereas adiponectin (10.6 ± 8.8 vs. 18.7 ± 14.9 ng/mL, P<0.001) were lower. With the accumulation of MetS components, thus increased CAP and LSM. When CAP and LSM were divided into quartiles, the number of MetS components increased with increasing quartiles, and CAP showed a stronger correlation with MetS than LSM. Binary Logistic regression analysis showed that CAP, age, neck circumference, adiponectin and fasting insulin were independent predictors for MetS. Even with no MetS components, subjects with CAP≥248dB/m had elevated BMI, neck and waist circumference, waist to hip ratio, increased fasting insulin, triglyceride, uric acid and reduced adiponectin. Conclusion: CAP showed a close relationship with MetS. Increased CAP was associated with increased body weight and dyslipidemia, reduced adiponectin even before the occurrence of MetS. Disclosure Z. Huang: None. W. Deng: None. H. Chen: None. K. Ng: None. Y. Li: None.