Abstract
Positron emission tomography (PET) using FDG tracer in cancer imaging relies on the increased glucose metabolism of tumor cells. We examined a fluorescent glucose, 2-NBDG, as an optical analog of FDG-PET for Barrett's Esophagus (BE)-related neoplasia. We performed a series of experiments using BE cell lines and a unique model, endoscopic mucosal resection (EMR) tissue, to assess the mechanism and feasibility of 2-NBDG as a probe for esophageal dysplasia.
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