Abstract
Rosacea, a chronic skin disorder, is characterized by inflammation and vascular abnormalities of the central facial skin. Cathelicidin LL-37 and VEGF are both specific contributors to physiopathology of Rosaceae and involved in inflammatory and angiogenesis pathways respectively. The aim of this work was to assess the soothing and anti-redness properties of a dermo-cosmetic ingredient in several models exposed to the different components of the rosacea environment. Firstly, the use of human normal keratinocyte primary cell line (NHEK) after a tangerine extract pre-treatment allowed us to show a decrease of VEGF and MMP9 gene expression and IL8 cytokine release after an stimulation by Rosaceae-like cocktail (TLR agonist, LL37, TNFα).
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