241. Risk for Bipolar Spectrum Disorders and Associations Between Inflammation and Reward-Related Brain Function

Abstract

Reward hypersensitivity increases risk for first onset and recurrences of bipolar spectrum disorders (BSDs), and individuals with BSDs exhibit elevated proinflammatory cytokines in manic, euthymic, and depressed states. Some recent studies find that inflammation is associated with elevated reward responsiveness when potential reward probability or magnitude is high.