Abstract
The skin provides a life-sustaining structural and immunological outer barrier of the body and has intrinsic mechanisms that protect the organism from diverse external threats including infections and mechanical injuries. Skin injury induces a complex, dynamic cellular program proceeding in sequential stages of inflammation, tissue growth and differentiation. Cells of the monocyte- macrophage lineage are an integral component of an effective repair response. Blood monocytes that are recruited to the side of tissue damage sense a variety of environmental cues of injured tissue and integrate those into a host protective wound healing response.
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