Abstract
Publisher Summary Sutherland has postulated that adenylate cyclase may be a lipoprotein whose functional activity in vivo may be dependent on the presence of membrane lipid. In recent years several observations have been reported demonstrating the critical role of phospholipids in hormone- responsive adenylate cyclase systems. Solubilization of membrane-bound adenylate cyclase abolishes its ability to be activated by hormones. Treatment of thyroid slices 8 and isolated liver plasma membranes with phospholipases results in a loss of hormone responsiveness to thyroid-stimulating hormone and glucagon, respectively. This Chapter describes the preparation of soluble cat myocardial adenylate cyclase and the use of specific phospholipids in restoring hormone-activation of the soluble enzyme.
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