Abstract
Background. Gastroesophageal reflux disease (GERD) is an urgent problem of modern gastroenterology as well as the most common pathology of the upper gastrointestinal tract; it is a chronic disease that significantly reduces the patient's quality of life, increases the risk of developing Barrett's esophagus and esophageal adenocarcinoma. Objective. To assess the potentials of multichannel intraluminal pH impedance monitoring in the diagnosis of esophageal diseases. Material and methods. In 3 patients with clinical and endoscopic signs of GERD esophageal multichannel intraluminal pH-impedance monitoring was performed using the diagnostic equipment Digitrapper pH-Z from Given Imaging (USA). Results. 24-hour esophageal pH monitoring enabled to verify the diagnosis of GERD, to reveal a hypersensitive esophagus and manifestations of nocturnal acid breakthrough. Conclusions. Multichannel intraluminal pH-impedance monitoring is the "gold standard" for the diagnosis of esophageal diseases; it significantly expands opportunities of gastroenterologists in the treatment of GERD.
Highlights
Gastroesophageal reflux disease (GERD) is an urgent problem of modern gastroenterology as well as the most common pathology of the upper gastrointestinal tract; it is a chronic disease that significantly reduces the patient's quality of life, increases the risk of developing Barrett's esophagus and esophageal adenocarcinoma
Заключение: общее количество зарегистрированных за время исследования рефлюксов у пациентки в пределах референсных значений, но наличие длительного кислого рефлюкса в ночное время указывает на наличие взаимосвязи с Гастроэзофагеальная рефлюксная болезнь (ГЭРБ), а изменение на pH-Z-грамме можно расценить как проявление кислотного ночного прорыва
В то же время имеющаяся связь возникновения симптомов (изжога и отрыжка) с физиологическим кислым рефлюксом на фоне нормальных показателей экспозиции кислоты в пищеводе может говорить о гиперчувствительности пищевода к рефлюксу
Summary
Gastroesophageal reflux disease (GERD) is an urgent problem of modern gastroenterology as well as the most common pathology of the upper gastrointestinal tract; it is a chronic disease that significantly reduces the patient's quality of life, increases the risk of developing Barrett's esophagus and esophageal adenocarcinoma. Многоканальная внутрипросветная рН-импедансометрия – «золотой стандарт» в диагностике заболеваний пищевода, существенно расширяет возможности гастроэнтерологов в лечении ГЭРБ. Ключевые слова: гастроэзофагеальная рефлюксная болезнь, гастроэзофагеальный рефлюкс, ГЭРБ, эзофагогастродуоденоскопия, ЭГДС, многоканальная внутрипросветная рН-импедансометрия пищевода.
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