Abstract
The effects of two dose regimens of cimetidine on 24 h intragastric acidity were investigated in six patients with duodenal ulcer. They received placebo capsules on the first day and cimetidine on the second day. Cimetidine 0·8 g/day decreased 24 h mean H + activity by 55% but 1·6 g/day decreased it by 67%, the difference being due to a greater nocturnal decrease in the high-dose group. Intragastric pH remained below 2·0 for much of the treatment day but similar values were found in four post-vagotomy patients. Cimetidine 0·8-1·6 g/day results in a decrease of intragastric acidity that is compatible with successful medical treatment of duodenal ulceration.
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