24-h glucose level and variability in response to carbohydrate overfeeding assessed using continuous glucose monitoring system are associated with daily carbohydrate intake

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The quantity gap between daily and loaded carbohydrates may affects blood glucose response to carbohydrate intake; however, no study has investigated the difference in 24-h span. This study aimed to determine differences in the 24-h glucose levels and variability in response to single-day carbohydrate overfeeding based on daily carbohydrate intake in healthy Japanese men. Twenty male college students completed a 3-day dietary record and were divided into two groups based on whether their daily carbohydrate intake exceeded the median intake (H-CHO) or not (L-CHO). Thereafter, the participants consumed a high-carbohydrate diet (carbohydrate 8.1g/kg/d) for 1 day. The 24-h glucose levels and glucose variability (CONGA1) were measured using a continuous glucose monitoring system. The mean daily carbohydrate intakes in the L-CHO and H-CHO groups were 3.9±0.5 and 5.8±0.6g/kg/d, respectively (p<0.001). The peak 24-h glucose level was not differ between the L-CHO group and the H-CHO group (8.0±0.8 vs. 8.0±1.0; p=0.886). The mean 24-h glucose level was higher in the L-CHO group than in the H-CHO group (6.0±0.3 vs. 5.6±0.3mmol/L; p=0.010). The CONGA1 was higher in the L-CHO group than in the H-CHO group (5.40±0.41 vs. 4.95±0.25; p=0.008). Mean glucose level and glucose variability in response to carbohydrate overfeeding were high in the individuals with small daily carbohydrate intake. These findings suggest that the large quantity gap between daily and loaded carbohydrates cause worse glucose control during carbohydrate overfeeding.