2397-PUB: PowerHouse: A Lifestyle Intervention for Youth at Risk for Type 2 Diabetes (T2D)

Abstract

The prevalence of T2D is increasing in youth partly because of the lack of effective prevention strategies. Lifestyle intervention is established for adult T2D prevention and family-based lifestyle intervention is the most efficacious non-surgical treatment of obesity in youth. We developed a 16-wk family-based program modeled after the U.S. Diabetes Prevention Program, using Expert Committee Recommendations Regarding the Prevention, Assessment and Treatment of Child and Adolescent Overweight and Obesity. Sessions included physical activity, separate adult/youth nutrition education and goal setting, and a shared meal. Youth inclusion criteria were age 7-18 y, BMI > 85th %ile, a caregiver to participate, and ≥ 2 risk factors: family history of T2D, maternal history of gestational diabetes, minority race/ethnicity. Paired t-tests were used to compare BMI and HbA1c at baseline (BL) and 4 months (M4) and at BL and 12 months (M12, data set currently incomplete). Between Feb 2017 and Nov 2018, 79 eligible youth enrolled (Table) the majority of whom had government-issued health insurance. Youth HbA1c was maintained at M4 (p = 1.0) and M12 (p = 0.45). Similarly, BMI SDS were stable at M4 (p = 0.67) and M12 (p = 0.12) while BMI scores increased at M4 (p = 0.007), but not at M12 (p = 0.23). As excessive weight-gain is correlated with T2D development, programs that maintain BMI could have significant impact on preventing or delaying T2D in youth. Disclosure H.K. El Mikati: None. J. Pike: None. K. Haberlin-Pittz: None. L. Yazel-Smith: None. B.M. McKinney: None. T.S. Hannon: Advisory Panel; Self; Eli Lilly and Company. Funding Indiana University School of Medicine; Indiana University