Abstract
three consecutive patients diagnosed gastric adenocarcinoma at National Taiwan University Hospital are enrolled. Anti-H. pylori antibody were evaluated for all the eligible cases and the invasive H. pylori tests were also performed. H. pylori status was defined as positive result from any of the invasive or non-invasive test. The pepsinogen (PG) method was performed for all the eligible cases. PG I < 70 ng/dl and PG I/II ratio < 3.0 were diagnosed as serological atrophic gastritis(SAG). Patients with SAG were considered as positive H. pylori status whether the H. pylori test result was negative or not. Results: We found four characteristics of HPNGC in comparison to HPPGC: (1) higher proportion of the proximal tumor location (19.7%, p=0.05), (2) more diffuse histologic type (61.0 %, p=0.03), (3) younger disease onset (58.1 years, p=0.003) and (4) more AJCC 7th stage IV cancer(40%, p=0.02). In addition, HPNGC came with worse long term overall survival than HPPGC(26.6% v.s 39.3%, p=0.04). In Cox regression model, the negative H. pylori status is an independent poor prognostic factor(HR: 1.40,CI:1.01-1.96, p = 0.04). In subgroup analysis, we found the prognostic effect of negative H. pylori status were particularly significant in the patients with AJCC 7thII or IIIa gastric cancer (HR: 2.84, 95% CI: 1.24-6.51, p = 0.01). Conclusion: The negativity of H. pylori status is an independent poor prognostic factor, particularly in patients with AJCC 7th stage II or IIIa. The negative H. pylori status might be a surrogate marker for guiding clinical management at this group
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
