238. Maternal Inflammation During Pregnancy and Offspring Psychopathology: Contributions of Gestational Timing and Fetal Sex

Abstract

Evidence suggests that infection during pregnancy is associated with increased risk of offspring psychopathology, such as depression. As most infections do not cross the placenta, maternal immune responses to infection have been considered as potentially contributing to this relationship. The present study sought to determine whether maternal inflammation during pregnancy was related to increased risk of offspring internalizing/externalizing symptoms in childhood and depressive symptoms during adolescence in a prospective, longitudinal birth cohort.