Abstract

1 Decrease in abdominal pain or discomfort ≥1.0 (5-pt scale) for ≥9 wks 2 CSBMs ≥3 and increased ≥1 and straining/BSFS ≥1.0 (5-pt/7-pt scale) for ≥9 wks 3 'Yes' on binary scale for ≥9 wks 4 Completely/considerably relieved ≥6 wks or at least somewhat relieved all 12 wks 5 Completely relieved for ≥2 wks or at least considerably relieved for all 4 wks for ≥2 mos 6 Improvement ≥1.0 (5-pt scale) for ≥9 wks 7 Decrease ≥50% in 500-pt IBSSSS scale at Week 12

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