237 Screening of soluble metabolites produced by probiotics on human dermal fibroblasts for anti-aging properties

Abstract

Dermal fibroblasts are producing the connective tissue with extracellular matrix (ECM) components, where type I collagen is the major structural protein. During aging the production ECM proteins decreases and synthesis of ECM degrading matrix metalloproteinases (MMPs) increases, leading to imbalanced homeostasis and wrinkle formation. Postbiotics, metabolites produced by bacteria, incubated on a monolayer of human dermal fibroblasts were used to model in vitro the effects of oral probiotic supplementation on dermis through the so-called gut-skin-axis.