234 - An electromagnetic homology patternings-based scoring retrosyntesis method on microbial transfected defined hybrids for the assessment of drug-like molecules and a accessible synthetically (AMPs) peptidomimetic-similar as a promising enhanced therapeutic antimicrobial agent

Abstract

Anti-infective drugs have had a key role in the contemporary world, contributing to dramatically decrease mortality rates caused by infectious diseases worldwide. Antimicrobial peptides (AMPs) are multifunctional effectors of the innate immune system of mucosal surfaces and present antimicrobial activity against a range of pathogenic viruses, bacteria, and fungi. However, the discovery and development of new antibacterial drugs is a crucial step to overcome the great challenge posed by the emergence of antibiotic resistance. In this review, we outline recent advances in the development of novel AMPs with improved antimicrobial activities that were achieved through characteristic structural design. In addition, we describe recent progress made to overcome some of the major limitations that have hindered peptide biosynthesis. Microbial Mutagenesis assays indicate that these residues are essential for the enzymatic activities. Gel affinity electrophoresis shows that these tryptophan residues are involved in the polysaccharide substrate binding. Also, electrostatic potential analysis indicates that almost the entire solvent accessible surface of CelB is negatively charged, which is consistent with the halophilic nature of this enzyme. A retrosynthesis-based scoring method based electromagnetic homology patternings on microbial transfected defined hybrids for the assessment of drug-like molecules on an accessible synthetically (AMPs) peptidomimetic-similar has been generated in this scientific article as a promising enhanced therapeutic antimicrobial agent. In this scientific article we annotated microbial transfected defined hybrids based on electromagnetic homology cell culturing patternings for the estimation and use of synthetic accessibility in a drug discovery rapid retrosynthesis-based scoring method for the assessment of synthetic accessibility of drug-like molecules where rational elaborated common strategies employed for the efficient in silico optimization of an accessible synthetically (AMPs) peptidomimetic-similar to an amphiphile-based pharmacophoric agent as a promising enhanced therapeutic antimicrobial agent.