233 Resting energy expenditure in patients with cystic fibrosis decreases after lung transplantation

Abstract

Objectives The resting energy expenditure (REE) in patients with cystic fibrosis (CF) with end-stage lung disease is increased due to chronic pulmonary infection. After lung transplantation (LTX), the pulmonary infection is decreased and therefore the REE might decrease as well. The aim of this study was to determine the REE in CF patients pre- and post-LTX. For this purpose we both measured and calculated the REE. Methods Included were 12 clinically stable pre-LTX CF patients, (9 females, age 15–50 y) and 12 post-LTX CF patients, (6 females, age 20–56 y). REE was measured in fasted stated by using indirect calorimetry, and calculated by using the prediction equations of Harris & Benedict (HB) 1919 and 1984, Schofield and World Health Organization (WHO) 1985. Results The median REE measured by indirect calorimetry was 1735 kcal (range 1379–2133) before and 1650 kcal (range 1287–1922) after lung transplantation. In 10 out of 12 pre-LTX CF patients (83%) including 2 patients with CF Conclusion After lung transplantation the median REE is lower than before lung transplantation. This possibly is due to a reduction in bacterial infections. Prediction equations do not take this into account. Measurement of REE is a more precise method to determine the energy needs for each individual CF LTX patient.