Abstract
Major Depressive Disorder (MDD) is a multifactorial disease with a heritability of 35-40%. BDNF Gene Val66Met (rs6265) variant has a well-established role in neuronal plasticity and decreased levels have been observed in MDD. Previous studies support that vulnerability to environmental stress is mediated by the rs6265 variant. Changes in methylation patterns in exon VI of BDNF are emerging as a possible explanation for how Early Life Stress (ELS) can disrupt BDNF expression. However, there is still controversy because most of these studies are in non-clinical populations.
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