Abstract
Extant data provide strong evidence for hippocampal hyperactivity in schizophrenia. We have found that volume deficits in early psychosis patients are more prominent in the anterior hippocampus. The origin of functional abnormalities along the hippocampal long axis is unclear. Models of hippocampal function have highlighted a role for the anterior hippocampus in scene processing and construction. Here we test the hypothesis that anterior hippocampal hyperactivity impairs the recruitment of this region during a cognitive task.
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