2327 PROSTATE CANCER STAGE, GRADE AND POSITIVE MARGIN RATE IN MEN WITH PSA ≥ 1 ng/ml UNDERGOING RADICAL PROSTATECTOMY: POPULATION DATA ANALYSIS

Abstract

You have accessJournal of UrologyProstate Cancer: Markers1 Apr 20112327 PROSTATE CANCER STAGE, GRADE AND POSITIVE MARGIN RATE IN MEN WITH PSA ≥ 1 ng/ml UNDERGOING RADICAL PROSTATECTOMY: POPULATION DATA ANALYSIS Sergey Shikanov, Norm D. Smith, Scott E. Eggener, Gregory P. Zagaja, and Arieh L. Shalhav Sergey ShikanovSergey Shikanov Chicago, IL More articles by this author , Norm D. SmithNorm D. Smith Chicago, IL More articles by this author , Scott E. EggenerScott E. Eggener Chicago, IL More articles by this author , Gregory P. ZagajaGregory P. Zagaja Chicago, IL More articles by this author , and Arieh L. ShalhavArieh L. Shalhav Chicago, IL More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2574AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Very low PSA may be associated with either non-aggressive low-volume prostate cancer or with undifferentiated tumors not producing PSA. Little is known about exact stage and grade distribution and positive margins rate in patients with PSA≤1 ng/ml undergoing radical prostatectomy. METHODS Data were abstracted from the Surveillance Epidemiology and End Results database. The study cohort consisted of 1009 men with PSA≤1 ng/ml diagnosed with prostate cancer between 2004 and 2006 and treated with radical prostatectomy. PSA values were obtained before prostate cancer diagnosis and any form of treatment. RESULTS Median (range) age was 59 (39–77) years and 9% (n=87) were African-Americans. One third (n=300) had non-palpable tumors (Figure 1), of these one fifth (n=52) had clinical stage T1ab. Eighty nine percent (n=899) had pathologically organ-confined disease and 66% (n=662) had Gleason score ≤ 6. Clinically palpable tumors were not associated with pathologically extraprostatic disease (chi-square P=0.5). The positive margin rate was 5% (44/899) for pT2 tumors, 16% (8/51) for pT3a tumors and 6% for pT2 and pT3a combined (52/950). CONCLUSIONS In men with PSA≤1 ng/ml, relatively high proportion of palpable tumors is not associated with high extracapsular extension rates on final pathology review. Despite very low PSA,only two thirds of these patients have Gleason score ≤6. Overall positive margin rate is low but not negligible. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e933 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sergey Shikanov Chicago, IL More articles by this author Norm D. Smith Chicago, IL More articles by this author Scott E. Eggener Chicago, IL More articles by this author Gregory P. Zagaja Chicago, IL More articles by this author Arieh L. Shalhav Chicago, IL More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...