2308: Measuring the changes of hemodynamic parameters by contrast ultrasound in diagnose liver metastases

Abstract

Objectives: To investigate the value of detecting the changes of hemodynamic parameters of hepatic artery and vein in diagnosis of liver metastasis by contrast-enhanced US. Methods: Fifty-two patients with liver metastases and 23 normal volunteers were recruited to be studied. Each subject was administrated with bolus injection of SonoVue (0.6 ml). The arrival times in the hepatic artery (ATHA), time to peak in the hepatic artery (TTPHA), peak intensity of the hepatic artery (PIHA), arrival times in the hepatic vein (ATHV), time to peak in the hepatic vein (TTPHV) and peak intensity of the hepatic vein (PIHV) were measured with time-intensity-curve software. The hepatic artery to vein transit time (HAVTT) was calculated as the difference between the arrival times in the hepatic artery and the hepatic vein. Results: ATHA, TTPHA, ATHV and TTPHV in study group were shorter than that of control group (p < 0.01). PIHA and PIHV were higher than that of control group (p < 0.01). HAVTT were shorter than that of control group (p < 0.001). The shortening of ATHV and HAVTT caused by hepatic metastases do not correlate with the vascularization, size and number of the hepatic metastases and the type of primary malignancies. Conclusions: Detecting the changes of hemodynamic parameters of hepatic artery and vein by contrast-enhanced US help to diagnose liver metastases.