Abstract
Histone deacetylases (HDACs) remove acetyl moieties from lysine residues of histones and other proteins to induce epigenetic change to DNA, and hence are important regulators of gene expression. Within the skin, they play a role in regulating keratinocyte proliferation and differentiation. To date, four classes of the HDACs have been identified: Class I (HDAC1, HDAC2, HDAC3, and HDAC8), class II HDACs (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10), class III (SIRT1-7) and class IV (HDAC11) but their role in keratinocyte biology is largely unknown.
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