230 History of meconium ileus is associated with low fat tissue mass in children and adolescents with cystic fibrosis

Abstract

Objectives Growth of patients with cystic fibrosis (CF) may be compromised. It was hypothesized that history of meconium ileus (MI) in children and adolescents with CF is a significant predictor of low bone mineral density (BMD)-total body less head (TBLH), low lean tissue mass (LTM) corrected for height and low fat mass (FM) irrespective of other prognostic factors. Methods Consecutive patients with CF were evaluated. The following explanatory variables were recorded: FEV1%, 25(OH) 2D levels, CFTR mutations, presence of diabetes mellitus, treatment with systemic corticosteroids and history of regular exercise. Weight, height and body mass index (BMI) were expressed as Z-scores. Dual-energy X-ray absorptiometry (DXA) was performed. BMD-TBLH, LTM and FM were measured and Z-scores were calculated. Odds ratios (OR) and 95% confidence intervals for having z-scores of BMD-TBLH, LTM or FM Results 108 patients (age 13.9±2.9 y; 8.1–19.9 y; 54.6% female) were evaluated. 19 (17.6%) subjects had history of MI. History of MI was associated significantly with low FM [OR (95% CI) = 5.38 (1.87–17.67); P = 0.002], but not with low BMD-TBLH [OR (95% CI) = 5.38 (0.99–29.04); P = 0.051] or low LTM [OR (95% CI) = 2.88 (0.97–8.52); P = 0.056]. The significant association between history of MI and low FM persisted after adjustment for other explanatory variables: OR (95% CI) = 8.52 (2.10–34.61); P = 0.003. Conclusion History of MI in children and adolescents with CF predicts low fat tissue mass.