230 Does antepartum vitamin D3 supplementation prevent gestational diabetes mellitus?

Abstract

To determine the if Vitamin D3 supplementation reduces the incidence of gestational diabetes (GDM). : A subgroup analysis of the efficacy of Vitamin D3 to prevent GDM was completed on a trial performed from 10/2016 - 4/2020. Women with a confirmed intrauterine pregnancy 12-16 weeks gestation were included. Women taking Vitamin D3 supplements, or a malabsorption disorder, carrying anomalous fetus or had diabetes mellitus were excluded. Women were assigned to receive daily Vitamin D3 3000IU or no supplement in addition to prenatal vitamins. Maternal demographic factors, maternal serum Vitamin D (25(OH)D) levels, and incidence of GDM were collected from charts. GDM was defined as a positive 2 hour 75g GTT or 3 hour 100g GTT. Parametric and nonparametric statistics were calculated with a p value of <0.05 as significant. The cohort consisted of 412 women, of which 385 met inclusion criteria. There were 192 in the Vitamin D3 supplementation group and 193 in the no supplementation group. There were no significant differences in baseline characteristics between the groups. (Table 1) The third trimester maternal serum 25(OH)D levels were significantly increased in the Vitamin D3 supplementation group when compared to the no supplementation group (29.57 +/- 11.84 ng/mL vs. 23.73 +/- 9.32 ng/mL; P<0.001. The overall incidence of GDM was 7.6% (29/385) and the incidence of GDM was similar between groups (6.2 vs. 6.9, RR 0.70, 95% CI 0.34-1.41). (Table 2) Antepartum Vitamin D3 supplementation raises baseline maternal serum 25(OH)D levels, but does not reduce the incidence of GDM.View Large Image Figure ViewerDownload Hi-res image Download (PPT)