23 Full Factorial Designs for Formulation and Evaluation of Non-Steroidal Anti-inflammatory Drug

Abstract

This study aimed to formulate ibuprofen fast-dissolving tablets using a natural super-disintegrant to enhance their anti-inflammatory activity. In this survey, three factors in a two-level (23) factorial design were employed to examine the effects of three factors, i.e., effects of Ocimum gratisimum mucilage [A], sodium starch glycolate [B], and croscarmellose sodium [C] on dependent variables such as in vitro method, in water absorption, and percent drug release at 5 minutes. The pH range for all formulations was 7.2 ± 0.24 to 7.2 ± 0.25. The drug content percentages ranged from 198.92 ± 0.78 to 201.5 ± 10.55%. The in vitro relationship is that after transient administration of the system, it remains intact for an extended period of time. Water absorption was in the range of 45.9 ± 0.15 to 99.9 ± 0.25%; optimized formulation water absorption was estimated to be approximately 55 ± 0.05% to 195 ± 0.040%. Formulations F2 and F4 reflected rapid drug release within 5 minutes, and all formulations except F3, F6, and F7 exhibited approximately 90% drug release within 10 minutes. Experience has shown that the independent variables chosen to have a significant effect on the dependent variable, demonstrating the robustness and adaptability of the design implied by optimization. The developed system could be a promising alternative strategy to increase ibuprofen retention in the stomach, thereby enhancing its therapeutic efficacy. It even offers the added benefit of reducing stomach irritation, tissue damage, and ulcers by avoiding direct contact of the drug with the gastric mucosa.