Abstract
Purpose: Homocysteine, together with its reactive thioester homocysteine thiolactone, is an endogenous excitatory agent in the CNS. The purpose of this study was to determine the effects of acute homocysteine thiolactone treatment on anxiety-related behavior in adult rats. Materials and methods: Adult Wistar albino rats were intraperitoneally treated with 0.9% NaCl (control group) or homocysteine thiolactone (1.3 mmol/kg, experimental group) 30 min prior to assessment of anxiety-related behavior in open filed (infra-red monitored) and light–dark transition (video monitored) tests. Number of rearings and time spent in the center of the open field were recorded using automatized system for rat behavior monitoring. Index of thigmotaxis (%) was calculated as ratio between distance of ambulation in periphery and total distance of ambulation. Time spent in the light part of the light–dark box were measured. Results: Number of rearings and time spent in the center of the open filed were decreased, while index of thigmotaxis were increased in experimental comparing to control group. Time spent in the light part of the light–dark box was decreased in rats from experimental group when compared with those from control group. Conclusion: These results indicate anxiogenic effects of acute homocysteine thiolactone in adult rats.
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