Abstract
Two of the most commonly used substances by adolescents are alcohol and cannabis. Alcohol use disorder (AUD) and cannabis use disorder (CUD) are associated with decision-making impairments in adolescents. Recent work has shown that adolescents with elevated levels of AUD symptoms show reduced striatal responsivity to reward in the context of both the monetary incentive delay task and an instrumental learning task. Theoretical models of substance use disorders (SUDs) suggest that novelty seeking is a key trait associated with the development of SUDs. Neurobiological models of novelty seeking indicate that novelty seeking is related to striatal reward processing and prediction error (PE) representation. The goal of the current study was to investigate neurocomputational impairments associated with AUD vs CUD symptom severity.
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