229P Identify the impact of SARS-CoV-2 on lung cancer tumorigenesis using host-pathogen interaction network analysis

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the coronavirus variant that started the global pandemic and infected more than 12 million victims around the world. SARS-CoV-2, similar to other viruses, interacts with the host proteins to reach the host cells and replicate its genome. Consequently, viral-host protein-protein interaction (PPI) identification could help predict the virus's behavior and its overlap with other pathogenic pathways. Several viruses have been known to closely trigger cancer pathways, serving as the starting point for tumorigenic mutations and even metastatic relapse.