Abstract
Photoageing is a complex process initiated by prolonged exposure to sunlight. In white Northern Europeans severe facial photoageing may result in two clinical phenotypes: ‘hypertrophic’ photoageing (HP) characterized by deep wrinkles and a leathery appearance or ‘atrophic’ photoageing (AP) characterized by telangiectasia and an unwrinkled appearance. AP individuals also have an increased propensity for developing keratinocyte cancers. Both HP and AP phenotypes are characterized by epidermal deterioration, yet the precise mechanism via which this occurs is unknown.
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