2288 THE RELATION BETWEEN DYSLIPIDEMIA WITH THE KLINEFELTER'S SYNDROME PATIENT

Abstract

You have accessJournal of UrologyInfertility: Evaluation1 Apr 20132288 THE RELATION BETWEEN DYSLIPIDEMIA WITH THE KLINEFELTER'S SYNDROME PATIENT Se Hwan Park, Dae Gi Jo, Hyo Serk Lee, Jin Ho Choe, Joong Shik Lee, Young Ho Kim, and Ju Tae Seo Se Hwan ParkSe Hwan Park SEOUL, Korea, Republic of More articles by this author , Dae Gi JoDae Gi Jo SEOUL, Korea, Republic of More articles by this author , Hyo Serk LeeHyo Serk Lee SEOUL, Korea, Republic of More articles by this author , Jin Ho ChoeJin Ho Choe SEOUL, Korea, Republic of More articles by this author , Joong Shik LeeJoong Shik Lee SEOUL, Korea, Republic of More articles by this author , Young Ho KimYoung Ho Kim Korea, Republic of More articles by this author , and Ju Tae SeoJu Tae Seo SEOUL, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2229AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The prevalence rate of metabolic syndrome in hypogonadism patients is known to be increased due to changes in body composition. Klinefelter's syndrome is a known genetic syndrome which presents with hypogonadism and there have been several studies looking into the association between Klinefelter's syndrome and metabolic syndromes. This study is aimed at proving our hypothesis that dyslipidemia, one of the criteria of metabolic syndrome is increased in Klinefelter's syndrome compared to control group. METHODS We have gathered date from two groups: 55 Klinefelter's syndrome patients who were examined at our hospital from March 2005 to May 2012 and 120 patients who underwent health screening from January 2011 to December 2011. The two groups were analyzed for height, weight, BMI, testosterone, total cholesterol, high-density lipoprotein(HDL), low-density lipoprotein(LDL), triglyceride(TG). We performed comparisons of each variable in the two groups. RESULTS Height and weight were significantly greater in Klinefelter's group, but no difference was found in BMI. Testosterone level in Klinefelter's group was significantly lower than the control group (2.4 ¡¾ 2.6 vs 5.2 ¡¾ 1.8, p<0.001). Compared with controls, TG in Klinefelter's group was increase than the control group (187.9 ¡¾ 192.1 vs 134.9 ¡¾ 127.8, p=0.004) and HDL was significantly decrease (44.0 ¡¾ 9.5 vs 51.2 ¡¾ 22.0, p=0.009). LDL and cholesterol were not significantly different between the two groups. (p=0.076, p=0.256, respectively). CONCLUSIONS Dyslipidemia indexes of the Klinefelter's syndrome patients were found to be abnormal compared to the control group. Based on our findings, we recommend that Klinefelter's syndrome patients who visit urology clinics for infertility counseling be screened for dyslipidemia and appropriately treated for their metabolic abnormalities. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e938 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Se Hwan Park SEOUL, Korea, Republic of More articles by this author Dae Gi Jo SEOUL, Korea, Republic of More articles by this author Hyo Serk Lee SEOUL, Korea, Republic of More articles by this author Jin Ho Choe SEOUL, Korea, Republic of More articles by this author Joong Shik Lee SEOUL, Korea, Republic of More articles by this author Young Ho Kim Korea, Republic of More articles by this author Ju Tae Seo SEOUL, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...