2282. Age-Stratified Analysis of Serotype-Specific Immunity Against Group B Streptococcus

Abstract

BackgroundDevelopment of group B streptococcus (GBS) vaccine is currently underway. In order to establish the immunization policy for the future, it is necessary to understand the basal immune level of risk groups in each country.MethodsThirty serum samples were collected from each risk group (neonates/infants, pregnant women and the elderly) between August 2016 and July 2017 at Korea University Guro hospital. Serotype-specific opsonic index (OI) was assessed using GBS multiplex opsonophagocytic killing assay (MOPA) against serotype Ia, III and V, which are most prevalent worldwide.ResultsThe mean age of neonates/infants, pregnant women, and the elderly was 1.3 months (range, 1–3 months), 31.9 years (range, 23–41 years) and 68.8 years (range 65–76 years), respectively. Baseline OI of each risk group measured by MOPA was shown in Table 1. The mean OI of serotype Ia was not significantly different among three risk groups (P = 0.156), but relatively lower in the neonates/infants group (mean ± standard deviation, 137 ± 278). For serotype III, the mean OI of neonates/infants (338 ± 623) was significantly lower compared with those of pregnant women (1,377 ± 1167) and old adults (1,350 ± 1741)(P = 0.002); Overall 60% of neonates/infants showed OI below 100. As for the serotype V, OI was particularly lower in neonates/infants (161 ± 445) compared with the elderly (3,669 ± 5,597) and pregnant women (9,414 ± 6,394) with statistically significant differences between three risk groups (P < 0.001).ConclusionConsidering the relatively low OI of neonates/infants despite high maternal titer, intrapartum GBS vaccination might be required to ensure efficient placental transfer of serotype-specific GBS antibodies with high avidity.Table 1.Comparison of Baseline Opsonic Indexes Between Risk Groups: Mean Opsonic Indexes and 95% Confidence IntervalsSerotypesGroupsOpsonic Index (Mean)95% CI P-ValueIaNeonates/infants13733–2410.596Pregnant women28517–552The Elderly2313–459IIINeonates/infants338105–5700.002Pregnant women1377941–1813The elderly1350700 - 2000VNeonates/infants161-5–327<0.001Pregnant women94146825–12003The elderly36691579–5759Disclosures All authors: No reported disclosures.