Abstract
Oxidative stress (OS) is a deleterious process involved in premature aging and in several inflammatory dermatosis (atopic dermatitis, psoriasis…). Beyond cutaneous cells, OS can also have adverse effects on free nerve endings innervating epidermis and that play a crucial role in cutaneous homeostasis. Little is known about the consequence of OS on these neurons and then, on skin. The aim of this study was to assess the effects of OS (H2O2) on sensory neurons derived from human induced pluripotent stem cells (iPSC) on human skin physiology (Reconstructed Human Epidermis, RHE) by using conditioned supernatants (CS).
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