2271-PUB: Correlation of Glycaemic Control with pH and Buffering Capacity of Saliva in Patients with Fibrocalculous Pancreatic Diabetes

Abstract

Fibrocalculous pancreatic diabetes (FCPD) is a form of diabetes secondary to chronic calcific pancreatitis. Microvascular and macrovascular complications of diabetes are reported in FCPD. Periodontitis is considered as the sixth complication of diabetes. Studies regarding the salivary pH, buffering capacity and periodontal health status of FCPD subjects are scarce in the literature. This Study comprised of 30 FCPD, 30 T2DM and 33 healthy controls. Study subjects were assessed for salivary pH and buffering capacity, modified gingival index, plaque index, OHI-s index, DMFT index, probing pocket depth and clinical attachment level and systemic parameters FPPG, PPPG, HbA1c, complete blood count, liver and renal function tests, FLP, ESR and CRP. The mean (±SD) salivary pH was 6.57 ± 0.63 in FCPD and 7.21±0.44 in T2DM groups (p<0.05) and buffering capacity was 4.5± 0.6 in FCPD and 5.38± 0.96 in T2DM groups(p<0.05). There was a significant negative correlation between HbA1c and salivary buffering capacity (Pearson correlation coefficient r=-0.46, p=0.012) and a weak negative correlation between HbA1c and salivary pH(r=-0.105, p=0.589) in FCPD group. The prevalence of periodontitis was 90% in FCPD and 100%T2DM groups respectively. The proportion of severe periodontitis was 56.7% in T2DM, 40% FCPD and 12.1% in control groups respectively. This study shows that the saliva is more acidic and buffering capacity is low in FCPD group compared to T2DM and control groups. As the glycaemic control worsens, salivary pH and buffering capacity decreased in FCPD subjects. The pathophysiologic mechanism responsible for the pancreatic gland destruction may also contribute to the changes in salivary pH and buffering capacity in FCPD subjects. Disclosure C. Radhakrishnan: None. R.J. Vadakkekuttical: None. S. Kozhithodi: None.