Abstract
Pulmonary arterial hypertension (PAH) is characterized by vascular obstruction that results in part from exaggerated proliferation of pulmonary arterial smooth muscle cells (PASMC). Here we examine the mechanisms of enhanced PASMC proliferation in Fawn-hooded rats (FHR), a strain with spontaneous PAH. We have previously observed a decrease in reactive oxygen species (ROS), including H2O2, in FHR pulmonary arteries(PA). This is associated with lowered expression of manganese superoxide dismutase (SOD2).
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