2264 DOES CURCUMIN PROTECT THE KIDNEY FOLLOWING ISCHEMIA REPERFUSION INJURY?

Abstract

You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation, Vascular Surgery II1 Apr 20122264 DOES CURCUMIN PROTECT THE KIDNEY FOLLOWING ISCHEMIA REPERFUSION INJURY? Fayez Hammad, Suhail Al-Salam, and Loay Lubbad Fayez HammadFayez Hammad Al Ain, United Arab Emirates More articles by this author , Suhail Al-SalamSuhail Al-Salam Al Ain, United Arab Emirates More articles by this author , and Loay LubbadLoay Lubbad Al Ain, United Arab Emirates More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2442AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There is limited number of studies which demonstrated a protective effect of curcumin on the markers of acute renal injury following ischemia-reperfusion injury. However, none of these studies have investigated the effect of curcumin on the glomerular and tubular renal functions which are probably more clinically relevant compared to the markers of acute renal injury. Thus, the aim of this study was to investigate the effect of curcumin on the alterations in renal functional parameters following different periods of warm ischemia-reperfusion injury in the rat. METHODS Male Wistar rats underwent left renal ischemia. Groups V-30 (n=10) and C-30 (n=10) underwent ischemia for 30 minutes whereas groups V-45 (n=8) and C-45 (n=8) underwent ischemia for 45 minutes. C-30 and C-45 groups received oral curcumin (200mg/kg/day) whereas V-30 and V-45 groups received a vehicle. The left renal artery blood flow was measured by a flowmeter before the induction of the renal ischemia and 15 minutes after kidney reperfusion. Serum tumor necrosis factor-alpha (TNF-á) was measured before and 2 days after ischemia. The functions of the ischemic left kidney and the contra-lateral non-ischemic right kidney were measured 2 days following the ischemia-reperfusion injury. RESULTS Ischemia-reperfusion caused significant increase in the serum level of TNF-á in all groups. However, post-ischemia levels in C-30 and C-45 groups were significantly lower than the V-30 and V-45 groups, respectively. Curcumin did not affect the alterations in renal artery blood flow, hemodynamic (glomerular filtration rate, renal blood flow) or tubular (urinary volume, urinary sodium and fractional excretion of sodium) functions in the C-30 or C-45 group. Curcumin improved the ischemia-induced histological alterations in the C-30 vs. V-30 groups. CONCLUSIONS Curcumin ameliorated the ischemia-induced alterations in serum TNF-á and associated histological changes but did not have any significant effect on glomerular and tubular functions following renal ischemia-reperfusion injury. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e913-e914 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Fayez Hammad Al Ain, United Arab Emirates More articles by this author Suhail Al-Salam Al Ain, United Arab Emirates More articles by this author Loay Lubbad Al Ain, United Arab Emirates More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...