Abstract
Cutibacterium acnes (CA) virulent strains can uncontrollably proliferate leading to, redness and pimples in acneic skin. But Staphylococcus epidermidis (SE) can selectively use fermentation initiators such as sucrose to produce short chain fatty acids such as succinic acid reducing CA growth. Based on this knowledge a complex of ingredients for acne care, bacterial and microbiotic reconstructed epidermis (mRHE) study models were developed. The aerobic growth of SE (ATCC12228) or anaerobic growth of virulent CA strain phylotype IA1 (ATCC6919 from facial acne lesions) were evaluated by turbidimetry after 3 days with/without 2% Biotic Complex (BC=biotic blend (sucrose, succinic and lactic acid) loaded in a complex made of pullulan, alginate, hyaluronate, glycerin and glycols).
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