225 Protective Effect of Anti-High-Mobility Group Box-1 (HMGB1) Antibody on Pulmonary Ischemia-Reperfusion Injury (IRI) in Miniature Swine

Abstract

measurements were done twice, before and one year after the lung transplantation. The measurements used were spirometry, Vital Capacity (VC) and Forced Expiratory Volyme in one second (FEV&1&), working capacity and 6-Minute Walk Test (6MWT). Health related quality of life was evaluated from the questionnaire Short Form 36 (SF-36). The SF -36 scores range from 0 to 100 with higher scores representing better health related quality of life. Results: 64 of the patients were transplanted during the study period and have done their one year follow-up. Pretransplant results showed that the median VC was 55 % of predicted values and the median FEV&1& was 27 % of predicted values before the lung transplantation and VC 76 % and FEV& 1 & 63 % one year after the operation. The median walking distance of the 6MWT was 240 m before the lung transplantation and 450 m one year after. The median result of the working capacity was 39 % of predicted values before the operation and 58 % one year after. The median value of physical health of SF-36 was 25 before the lung transplantation and 48 one year after and mental health 50 before and 56 after. Conclusions: This study has shown that the lung transplanted patients’ physical capacity and health related quality of life improved significantly one year after lung transplantation.