Abstract
Introduction: Procalcitonin (PCT) was originally described in 1984 as a 116 aminoacid protein with a molecular weight of 14.5 kDa. The PCT gene, referred to as Calc-1, is located on chromosome 11p15.4 and was sequenced in 1989. The promoter has sites for basal transcription factors but more interestingly, also has sites for Nuclear factor |[kappa]||[beta]| (NF|[kappa]||[beta]|) and activator protein -1 (AP-1), factors induced under inflammatory conditions. Diabetes Mellitus is associated with oxidative stress and elevation of advanced glycation end products (AGEs). AGEs are produced by a non-enzymatic, maillard reaction between reducing sugars and either proteins or lipids. AGEs interacts the receptor for advanced glycation end products (RAGE) and RAGE activation is caused by elevation of transcriptional factors NF|[kappa]||[beta]| and AP-1. These factors induce procalcitonin gene expression. The aim of this study was to determine whether or not procalcitonin is a specific marker in patients with diabetic complications.
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