224 Risk factors and outcomes for sepsis in cutaneous T cell lymphoma compared to in other non-Hodgkin lymphomas

Abstract

Cutaneous T cell lymphoma (CTCL) patients often suffer from recurrent skin infections that progress to sepsis. However, it is unknown how risk factors and outcomes differ between sepsis in CTCL versus in other non-Hodgkin lymphomas (NHL). We analyzed a retrospective cohort of 97 CTCL (40% mycosis fungoides, 40% Sézary syndrome) and 89 non-CTCL NHL patients with sepsis and positive blood cultures at a single U.S. academic institution, 2000-2021. Median follow-up time was 159 months. CTCL patients with sepsis were on average older than other NHL patients with sepsis (mean age 62.3 versus 55.7 years, p=0.003), experienced more episodes (mean 1.9 versus 1.4 episodes, p<0.0001), and more often died of sepsis within 30 days (54% versus 25%, p=0.041).