Abstract
The alpha dose to cells in bronchial airways in the beagle dog during historical exposures to 222Rn decay products is calculated using updated information on airway morphometry, cell nucleus depth, mucus thickness, physical dosimetry and atmospheric characteristics. The alpha dose per unit exposure to basal cell nuclei in the upper airways ranges from 2 to 7 mGy.WLM-1 (excluding the trachea) depending upon the exposure protocol used by the Institute (Battelle Northwest Laboratories versus University of Rochester). The dose to alveolar tissue is 3 mGy.WLM-1. In the human lung, the dose factor for the bronchial airways is 9 mGy.WLM-1 and for the pulmonary parenchyma 0.5 mGy.WLM-1. The human tumours appear primarily in the first few branching airway generations while the only tumours observed in the animals were in the bronchioloalveolar region suggesting a difference in cell sensitivity to alpha radiation.
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