Abstract
Background: The introduction of foreign proteins from animal lung-based surfactants into the airways of premature infants may provide an antigenic stimulus with a possible immunological response to these proteins. Recently the Butantan Institute (Brazil) produced a porcine pulmonary surfactant preparation obtained by organic extraction coupled with adsorption on a cellulose derivative, composed mainly by phospholipids with two hydrophobic polypeptides, SP-B and SP-C. This new surfactant contains 76% of phosphatidylcholine, 6–8% of phosphatidylethanolamine, 6% of phosphatidylinositol + phosphatidylserine, and 4–6% of sphingomyelin; 30–35% of the phosphatidylcholine was dipalmitoylphosphatidylcholine. The total content of protein is 5.6% of the surfactant preparation. The objective of this study was to analyze in rabbits the immunogenicity of the Butantan Institute surfactant preparation compared with commercial available lung surfactant preparations.
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