2214-PUB: Cytokine Profile in Patients with Type 2 Diabetes Mellitus and Evolution of ST-Elevation Acute Myocardial Infarction of Buryat Ethnic Group

Abstract

Inflammatory processes during type 2 diabetes mellitus (T2D) and evolution of ST-elevation acute myocardial infarction (STEMI) are different in various ethnic groups. Buryats are the main northern group of Mongolians, they are a core population of Siberia. We have examined the associations between cytokines and high sensitivity C-reactive protein (hs-CRP) in 14 patients (36% males) with T2D and STEMI of Buryat ethnic group (60 years, diabetes duration 7.9 years, A1c 8.0%); in 21 Caucasian patients (48% males) with T2D and STEMI (60 years, diabetes duration 8.0 years, A1c 7.9%); in 13 patients (77% males, 59 years) with STEMI without T2D of Buryat ethnic group and 18 Caucasian patients (72% males, 61 years) with STEMI without T2D.Buryat patients with T2D and STEMI had higher hs-CRP and lower interleukin-8 (IL-8) and interleukin-10 (IL-10) compared to Buryat patients with STEMI without T2D. Caucasian patients with T2D and STEMI had higher hs-CRP and lower tumor necrosis factor alpha (TNF-α) compared to Caucasian patients with STEMI without T2D. Buryat patients with T2D and STEMI had lower interleukin-6 (IL-6), IL-8, IL-10 and hs-CRP compared to Caucasian patients with T2D and STEMI. We have determined decreased secretion of cytokines and hs-CRP in patients with T2D and STEMI of Buryat ethnic group compared to Caucasian patients. Disclosure T. Bardymova: None. K. Protasov: None. T. Belochvostikova: None. S. Tsyretorova: None. M. Mistiakov: None. O. Donirova: None. M. Berezina: None.