22 SERUM URIC ACID LEVEL AS A POTENTIAL BIOCHEMICAL MARKER IN DETERMINING THE SEVERITY AND DURATION OF HYPERTENSION: A PROSPECTIVE OBSERVATIONAL ANALYTIC STUDY

Abstract

Background: Recent studies demonstrated that uric acid levels are associated with hypertension, these suggest that unexplained hyperuricemia could be a risk marker in patients with hypertension. Objective: Aims of this study was to determine the role of uric acid as potential biomarker in relation to essential hypertension. Method: This study was an observational analytic study design. 150 subjects were studied, divided into 2 groups, the first group was 100 essential hypertension patients without comorbid factors, and control group included 50 healthy subjects. Subject's age group 30-60 years. All the subject's blood pressure was measured using mercury sphygmomanometer on 3 different occasions, then serum uric acid was measured by taking blood sample and sent to the laboratory for analysis with uricase/PAP method. The data were analyzed to assess the significant correlation and difference in means of the studied variables between two different groups. Result: The mean level of serum uric acid is significantly higher in hypertension group compared to control group (6.2 ± 1.8 vs 5.4 ± 1.4, p-value 0.016). Serum uric acid based on the duration of hypertension showed the difference compared to control group (<5 years: 5.8 ± 1.4 vs 35 years: 7.0 ± 2.4, p-value 0.004). There is relationship between hypertension and uric acid level (153.8 ± 10.1 vs 118.3 ± 9.0, p-value 0.07; 93.7 ± 7.8 vs 75.9 ± 6.3, p-value 0.03) Conclusion: Serum uric acid can be considered as a potential biomarker in determining the severity and duration of hypertension.